Lipiarmycin, a new antibiotic from Actinoplanes. II. Isolation, chemical, biological and biochemical characterization.
نویسندگان
چکیده
Lipiarmycin, a metabolite of Actinoplanes deccanensis nov. sp. (PARENTI et al.), has been isolated in pure form. It has a molecular formula C52 CONGRUENT TO 54H74 CONGRUENT TO 76Cl2O19, (M.W. = 1,073 CONGRUENT TO 1,099). From its chemical and physico-chemical characteristics, lipiarmycin can be considered a new antibiotic. Lipiarmycin is highly active against Gram-positive bacteria, including strains resistant to the medically important antibiotics and protects mice experimentally infected with Streptococcus haemolyticus. Liparmycin inhibits growth of susceptible bacteria by interfering with RNA synthesis.
منابع مشابه
Structure and biological activity of lipiarmycin B.
Actinoplanes deccanensis ATCC 21983, the producer of antibiotics lipiarmycin A3 and A4, furnished also a related antibiotic designated lipiarmycin B, active against Gram-positive bacteria, including anaerobes, and against Neisseria. The structures of the two major components, B3 and B4, were elucidated from their physico-chemical properties, 1H and 13C NMR spectra and fast atom bombardment mass...
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عنوان ژورنال:
- The Journal of antibiotics
دوره 28 4 شماره
صفحات -
تاریخ انتشار 1975